| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Dehydrodolichyl diphosphate synthase complex subunit DHDDS is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DHDDS |
| Gene ID: |
79947 |
| Uniprot ID: |
DHDDS_HUMAN |
| Specificity: |
This antibody detects endogenous levels of DHDDS at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human DHDDS |
| Function | With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. |
| Protein Name | Dehydrodolichyl Diphosphate Synthase Complex Subunit DhddsCis-IsoprenyltransferaseCitCis-IptaseCis-Prenyltransferase Subunit HcitEpididymis Tissue Protein Li 189m |
| Database Links | Reactome: R-HSA-446199Reactome: R-HSA-4755609 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinColocalizes With Calnexin |
| Alternative Antibody Names | Anti-Dehydrodolichyl Diphosphate Synthase Complex Subunit Dhdds antibodyAnti-Cis-Isoprenyltransferase antibodyAnti-Cit antibodyAnti-Cis-Iptase antibodyAnti-Cis-Prenyltransferase Subunit Hcit antibodyAnti-Epididymis Tissue Protein Li 189m antibodyAnti-DHDDS antibodyAnti-HDS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
