Anti-DHDDS antibody (STJA0008969)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human DHDDS
General Information
| Short Description | Rabbit polyclonal anti-Dehydrodolichyl diphosphate synthase complex subunit DHDDS for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DHDDS |
| Gene ID | 79947 |
| Uniprot ID | DHDDS_HUMAN |
| Immunogen | Synthesized peptide derived from human DHDDS |
| Specificity | This antibody detects endogenous levels of DHDDS at Human, Mouse |
Additional Info
| Function | With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. |
| Protein Name | Dehydrodolichyl Diphosphate Synthase Complex Subunit DhddsCis-IsoprenyltransferaseCitCis-IptaseCis-Prenyltransferase Subunit HcitEpididymis Tissue Protein Li 189m |
| Database Links | Reactome: R-HSA-446199Reactome: R-HSA-4755609 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinColocalizes With Calnexin |
| Alternative Antibody Names | Anti-Dehydrodolichyl Diphosphate Synthase Complex Subunit Dhdds antibodyAnti-Cis-Isoprenyltransferase antibodyAnti-Cit antibodyAnti-Cis-Iptase antibodyAnti-Cis-Prenyltransferase Subunit Hcit antibodyAnti-Epididymis Tissue Protein Li 189m antibodyAnti-DHDDS antibodyAnti-HDS antibody |
Information sourced from Uniprot.org