Anti-DGKD antibody (41-90 aa) (STJ92698)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human DGKD at the amino acid range 41-90
General Information
| Short Description | Rabbit polyclonal anti-Diacylglycerol kinase delta (41-90 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DGKD |
| Gene ID | 8527 |
| Uniprot ID | DGKD_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human DGKD at the amino acid range 41-90 |
| Immunogen Region | 41-90 aa |
| Specificity | DGK-Delta Polyclonal Antibody detects endogenous levels of DGK-Delta protein. |
Additional Info
| Post Translational Modifications | Isoform 1: Phosphorylated. Phosphorylation by PKC induced by phorbol esters prevents homooligomerization and promotes association with membranes. |
| Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development. May also regulate clathrin-dependent endocytosis. |
| Protein Name | Diacylglycerol Kinase DeltaDag Kinase Delta130 Kda Diacylglycerol KinaseDiglyceride Kinase DeltaDgk-Delta |
| Database Links | Reactome: R-HSA-114508 |
| Cellular Localisation | MembraneClathrin-Coated PitCytoplasmIsoform 1: Cell MembranePeripheral Membrane ProteinIsoform 1 Translocation From Cytoplasm To The Plasma Membrane Is Induced By Phorbol EstersPhorbol Esters Induce The Conversion Into The Monomeric Form Which Can Translocate To The Plasma Membrane |
| Alternative Antibody Names | Anti-Diacylglycerol Kinase Delta antibodyAnti-Dag Kinase Delta antibodyAnti-130 Kda Diacylglycerol Kinase antibodyAnti-Diglyceride Kinase Delta antibodyAnti-Dgk-Delta antibodyAnti-DGKD antibodyAnti-KIAA0145 antibody |
Information sourced from Uniprot.org