| Post Translational Modifications | Isoform 1: Phosphorylated. Phosphorylation by PKC induced by phorbol esters prevents homooligomerization and promotes association with membranes. |
| Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development. May also regulate clathrin-dependent endocytosis. |
| Protein Name | Diacylglycerol Kinase DeltaDag Kinase Delta130 Kda Diacylglycerol KinaseDiglyceride Kinase DeltaDgk-Delta |
| Database Links | Reactome: R-HSA-114508 |
| Cellular Localisation | MembraneClathrin-Coated PitCytoplasmIsoform 1: Cell MembranePeripheral Membrane ProteinIsoform 1 Translocation From Cytoplasm To The Plasma Membrane Is Induced By Phorbol EstersPhorbol Esters Induce The Conversion Into The Monomeric Form Which Can Translocate To The Plasma Membrane |
| Alternative Antibody Names | Anti-Diacylglycerol Kinase Delta antibodyAnti-Dag Kinase Delta antibodyAnti-130 Kda Diacylglycerol Kinase antibodyAnti-Diglyceride Kinase Delta antibodyAnti-Dgk-Delta antibodyAnti-DGKD antibodyAnti-KIAA0145 antibody |
Information sourced from Uniprot.org
