| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Dennd4c (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 210kDa band observed in Mouse Spleen lysates (calculated MW of 211kDa according to NP_908976.1). Recommended concentration: 0.5-2µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Immunogen Region: | Internal |
| Accession Number: | NP_908976.1; NP_001074483.1 |
| Specificity: | This antibody is expected to recognize both reported isoforms (NP_908976.1; NP_001074483.1). |
| Immunogen Sequence: | RFKPQSPYRAYKDRS |
| Function | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. |
| Protein Name | Denn Domain-Containing Protein 4c |
| Database Links | Reactome: R-MMU-8876198 |
| Cellular Localisation | Cytoplasmic Vesicle MembraneCell MembraneCytoplasmCytosolAssociates With Slc2a4/Glut4 Storage Vesicles |
| Alternative Antibody Names | Anti-Denn Domain-Containing Protein 4c antibodyAnti-Dennd4c antibody |
Information sourced from Uniprot.org