Anti-DENND4A antibody (1500-1650) (STJ118535)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DENND4A (1500-1650) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DENND4A |
| Gene ID | 10260 |
| Uniprot ID | MYCPP_HUMAN |
| Immunogen Region | 1500-1650 |
| Immunogen Sequence | RPGRYFLKSSPSTENMHFPS SISSQTRQSCISTSASGLDT SALSVQGNFDLNSKSKLQEN FCTRSIQIPANRSKTAMSKC PIFPMARSISTSGPLDKEDT GRQKLISTGSLPATLQGATD SLGLEWHLPSPDPVTVPYLS PLVVWKELESL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1500-1650 of human DENND4A (NP_005839.3). |
Additional Info
| Tissue Specificity | Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner. |
| Function | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. |
| Protein Name | C-Myc Promoter-Binding ProteinDenn Domain-Containing Protein 4a |
| Database Links | Reactome: R-HSA-8876198 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-C-Myc Promoter-Binding Protein antibodyAnti-Denn Domain-Containing Protein 4a antibodyAnti-DENND4A antibodyAnti-IRLB antibodyAnti-MYCPBP antibody |
Information sourced from Uniprot.org