| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DENND4A (1500-1650) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DENND4A |
| Gene ID: |
10260 |
| Uniprot ID: |
MYCPP_HUMAN |
| Immunogen Region: |
1500-1650 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1500-1650 of human DENND4A (NP_005839.3). |
| Immunogen Sequence: |
RPGRYFLKSSPSTENMHFPS SISSQTRQSCISTSASGLDT SALSVQGNFDLNSKSKLQEN FCTRSIQIPANRSKTAMSKC PIFPMARSISTSGPLDKEDT GRQKLISTGSLPATLQGATD SLGLEWHLPSPDPVTVPYLS PLVVWKELESL |
| Tissue Specificity | Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner. |
| Function | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. |
| Protein Name | C-Myc Promoter-Binding ProteinDenn Domain-Containing Protein 4a |
| Database Links | Reactome: R-HSA-8876198 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-C-Myc Promoter-Binding Protein antibodyAnti-Denn Domain-Containing Protein 4a antibodyAnti-DENND4A antibodyAnti-IRLB antibodyAnti-MYCPBP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunofluorescence analysis of paraffin-embedded Mouse colon tissue using [KD Validated] ZO-1 Rabbit polyclonal antibody (STJ11105590) at a dilution of 1:200 (40x lens). Secondary antibody:Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining. Perform high pressure antigen retrieval with 0. 01 M citrate buffer (pH 6. 0) prior to IF staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/178234/370532/STJ11105590_1__25608.1713136486.jpg?c=1 "Immunofluorescence analysis of paraffin-embedded Mouse colon tissue using [KD Validated] ZO-1 Rabbit polyclonal antibody (STJ11105590) at a dilution of 1:200 (40x lens). Secondary antibody:Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining. Perform high pressure antigen retrieval with 0. 01 M citrate buffer (pH 6. 0) prior to IF staining.")
