Anti-DEF6 antibody [ZN51] (STJA0033324)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenFull length human recombinant protein of human DEF6 (NP_071330) produced in HEK293T cell.
General Information
| Short Description | Mouse monoclonal anti-DEF6 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ZN51 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 0.5-1.0 mg/mL |
| Purification | Affinity Chromatography |
| Dilution Range | IHC 1:50-1:100 |
| Formulation | PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | DEF6 |
| Gene ID | 50619 |
| Uniprot ID | DEFI6_HUMAN |
| Immunogen | Full length human recombinant protein of human DEF6 (NP_071330) produced in HEK293T cell. |
Additional Info
| Tissue Specificity | Broadly expressed in the immune system. Highly expressed in T cells. |
| Post Translational Modifications | Tyrosine-phosphorylated by tyrosine-protein kinase LCK in response to T-cell activation. |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling. |
| Protein Name | Differentially Expressed In Fdcp 6 HomologDef-6Irf4-Binding Protein |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404 |
| Cellular Localisation | CytoplasmCell MembraneNucleusCytoskeletonPerinuclear RegionCell ProjectionFilopodiumRecruited To The Plasma Membrane Upon Binding Phosphatidylinositol 345-TrisphosphateBinds To Actin Filaments |
| Alternative Antibody Names | Anti-Differentially Expressed In Fdcp 6 Homolog antibodyAnti-Def-6 antibodyAnti-Irf4-Binding Protein antibodyAnti-DEF6 antibodyAnti-IBP antibody |
Information sourced from Uniprot.org