| Tissue Specificity | Broadly expressed in the immune system. Highly expressed in T cells. |
| Post Translational Modifications | Tyrosine-phosphorylated by tyrosine-protein kinase LCK in response to T-cell activation. |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling. |
| Protein Name | Differentially Expressed In Fdcp 6 HomologDef-6Irf4-Binding Protein |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404 |
| Cellular Localisation | CytoplasmCell MembraneNucleusCytoskeletonPerinuclear RegionCell ProjectionFilopodiumRecruited To The Plasma Membrane Upon Binding Phosphatidylinositol 345-TrisphosphateBinds To Actin Filaments |
| Alternative Antibody Names | Anti-Differentially Expressed In Fdcp 6 Homolog antibodyAnti-Def-6 antibodyAnti-Irf4-Binding Protein antibodyAnti-DEF6 antibodyAnti-IBP antibody |
Information sourced from Uniprot.org
