| Function | Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and hematopoietic homeostasis. Recognizes foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses. Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1. Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity. In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses. Selectively modulates the transcription of certain immunity-associated genes by regulating their alternative splicing. Binds to RNA (R)-loops, structures consisting of DNA/RNA hybrids and a displaced strand of DNA that occur during transcription, and prevents their accumulation, thereby maintaining genome stability. Also participates in pre-mRNA splicing, translational regulation and snoRNA processing, which is essential for ribosome biogenesis. |
| Protein Name | Probable Atp-Dependent Rna Helicase Ddx41Dead Box Protein 41Dead Box Protein Abstrakt Homolog |
| Database Links | Reactome: R-HSA-1834941Reactome: R-HSA-3134975Reactome: R-HSA-3270619Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusCytoplasmPredominantly Present In The Nucleus And Traffics To The CytoplasmSpecifically In The Perinuclear RegionAfter Dna Stimulation |
| Alternative Antibody Names | Anti-Probable Atp-Dependent Rna Helicase Ddx41 antibodyAnti-Dead Box Protein 41 antibodyAnti-Dead Box Protein Abstrakt Homolog antibodyAnti-DDX41 antibodyAnti-ABS antibody |
Information sourced from Uniprot.org
