Anti-DDX41 antibody (STJA0009724)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human DDX41
General Information
| Short Description | Rabbit polyclonal anti-Probable ATP-dependent RNA helicase DDX41 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DDX41 |
| Gene ID | 51428 |
| Uniprot ID | DDX41_HUMAN |
| Immunogen | Synthesized peptide derived from human DDX41 |
| Specificity | This antibody detects endogenous levels of DDX41 at Human, Mouse |
Additional Info
| Function | Multifunctional protein that participates in many aspects of cellular RNA metabolism. Plays pivotal roles in innate immune sensing and hematopoietic homeostasis. Recognizes foreign or self-nucleic acids generated during microbial infection, thereby initiating anti-pathogen responses. Mechanistically, phosphorylation by BTK allows binding to dsDNA leading to interaction with STING1. Modulates the homeostasis of dsDNA through its ATP-dependent DNA-unwinding activity and ATP-independent strand-annealing activity. In turn, induces STING1-mediated type I interferon and cytokine responses to DNA and DNA viruses. Selectively modulates the transcription of certain immunity-associated genes by regulating their alternative splicing. Binds to RNA (R)-loops, structures consisting of DNA/RNA hybrids and a displaced strand of DNA that occur during transcription, and prevents their accumulation, thereby maintaining genome stability. Also participates in pre-mRNA splicing, translational regulation and snoRNA processing, which is essential for ribosome biogenesis. |
| Protein Name | Probable Atp-Dependent Rna Helicase Ddx41Dead Box Protein 41Dead Box Protein Abstrakt Homolog |
| Database Links | Reactome: R-HSA-1834941Reactome: R-HSA-3134975Reactome: R-HSA-3270619Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusCytoplasmPredominantly Present In The Nucleus And Traffics To The CytoplasmSpecifically In The Perinuclear RegionAfter Dna Stimulation |
| Alternative Antibody Names | Anti-Probable Atp-Dependent Rna Helicase Ddx41 antibodyAnti-Dead Box Protein 41 antibodyAnti-Dead Box Protein Abstrakt Homolog antibodyAnti-DDX41 antibodyAnti-ABS antibody |
Information sourced from Uniprot.org