| Function | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Required for the assembly of both SST3A- and SS3B-containing OST complexes. |
| Protein Name | Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 48 Kda SubunitDdost 48 Kda SubunitOligosaccharyl Transferase 48 Kda Subunit |
| Database Links | Reactome: R-HSA-1799339Reactome: R-HSA-446203Reactome: R-HSA-6798695Reactome: R-HSA-879415Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 48 Kda Subunit antibodyAnti-Ddost 48 Kda Subunit antibodyAnti-Oligosaccharyl Transferase 48 Kda Subunit antibodyAnti-DDOST antibodyAnti-KIAA0115 antibodyAnti-OST48 antibodyAnti-OK antibodyAnti-SW-cl.45 antibody |
Information sourced from Uniprot.org
