| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DDOST (40-300) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:100-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DDOST |
| Gene ID: |
1650 |
| Uniprot ID: |
OST48_HUMAN |
| Immunogen Region: |
40-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human DDOST (NP_005207.2). |
| Immunogen Sequence: |
VCASGPRTLVLLDNLNVRET HSLFFRSLKDRGFELTFKTA DDPSLSLIKYGEFLYDNLII FSPSVEDFGGNINVETISAF IDGGGSVLVAASSDIGDPLR ELGSECGIEFDEEKTAVIDH HNYDISDLGQHTLIVADTEN LLKAPTIVGKSSLNPILFRG VGMVADPDNPLVLDILTGSS TSYSFFPDKPITQYPHAVGK NTLLIAGLQARNNARVIFSG SLDFFSDSFFNSAVQKAAP |
| Function | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Required for the assembly of both SST3A- and SS3B-containing OST complexes. |
| Protein Name | Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 48 Kda SubunitDdost 48 Kda SubunitOligosaccharyl Transferase 48 Kda Subunit |
| Database Links | Reactome: R-HSA-1799339Reactome: R-HSA-446203Reactome: R-HSA-6798695Reactome: R-HSA-879415Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 48 Kda Subunit antibodyAnti-Ddost 48 Kda Subunit antibodyAnti-Oligosaccharyl Transferase 48 Kda Subunit antibodyAnti-DDOST antibodyAnti-KIAA0115 antibodyAnti-OST48 antibodyAnti-OK antibodyAnti-SW-cl.45 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
