Anti-DCUN1D3 antibody (205-255 aa) (STJ196139)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human DCNL3 at the amino acid range 205-255
General Information
| Short Description | Rabbit polyclonal anti-DCN1-like protein 3 (205-255 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DCUN1D3 |
| Gene ID | 123879 |
| Uniprot ID | DCNL3_HUMAN |
| Immunogen | Synthesized peptide derived from the human DCNL3 at the amino acid range 205-255 |
| Immunogen Region | 205-255 aa |
| Specificity | This antibody detects endogenous levels of DCNL3 at Human/Mouse/Rat |
Additional Info
| Function | Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage. At the cell membrane, can promote and as well inhibit cullins neddylation. |
| Protein Name | Dcn1-Like Protein 3Dcnl3Dcun1 Domain-Containing Protein 3Defective In Cullin Neddylation Protein 1-Like Protein 3Squamous Cell Carcinoma-Related Oncogene 3 |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | Cell MembraneCytoplasmNucleusPerinuclear RegionAfter Uvc TreatmentThe Protein Enters To The Nucleus GraduallyCell Membrane Localization Is Essential For Cul3 Neddylation |
| Alternative Antibody Names | Anti-Dcn1-Like Protein 3 antibodyAnti-Dcnl3 antibodyAnti-Dcun1 Domain-Containing Protein 3 antibodyAnti-Defective In Cullin Neddylation Protein 1-Like Protein 3 antibodyAnti-Squamous Cell Carcinoma-Related Oncogene 3 antibodyAnti-DCUN1D3 antibodyAnti-SCCRO3 antibody |
Information sourced from Uniprot.org