| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DCN1-like protein 3 (205-255 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DCUN1D3 |
| Gene ID: |
123879 |
| Uniprot ID: |
DCNL3_HUMAN |
| Immunogen Region: |
205-255 aa |
| Specificity: |
This antibody detects endogenous levels of DCNL3 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human DCNL3 at the amino acid range 205-255 |
| Function | Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage. At the cell membrane, can promote and as well inhibit cullins neddylation. |
| Protein Name | Dcn1-Like Protein 3Dcnl3Dcun1 Domain-Containing Protein 3Defective In Cullin Neddylation Protein 1-Like Protein 3Squamous Cell Carcinoma-Related Oncogene 3 |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | Cell MembraneCytoplasmNucleusPerinuclear RegionAfter Uvc TreatmentThe Protein Enters To The Nucleus GraduallyCell Membrane Localization Is Essential For Cul3 Neddylation |
| Alternative Antibody Names | Anti-Dcn1-Like Protein 3 antibodyAnti-Dcnl3 antibodyAnti-Dcun1 Domain-Containing Protein 3 antibodyAnti-Defective In Cullin Neddylation Protein 1-Like Protein 3 antibodyAnti-Squamous Cell Carcinoma-Related Oncogene 3 antibodyAnti-DCUN1D3 antibodyAnti-SCCRO3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
