| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Dermcidin is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DCD |
| Gene ID: |
117159 |
| Uniprot ID: |
DCD_HUMAN |
| Specificity: |
This antibody detects endogenous levels of DCD at Human |
| Immunogen: |
Synthesized peptide derived from human DCD |
| Function | DCD-1: Found in sweat, has an antimicrobial activity during early bacterial colonization. The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen membranes. Once inserted in bacteria membranes forms anion channels probably altering the transmembrane potential essential for bacterial survival. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues. Survival-promoting peptide: Promotes survival of neurons and displays phosphatase activity. It may bind IgG. |
| Protein Name | DermcidinPreproteolysin Cleaved Into - Survival-Promoting Peptide - Dcd-1 |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedSurvival-Promoting Peptide: SecretedDcd-1: SecretedMembranePeripheral Membrane ProteinSingle-Pass Membrane ProteinThe Secreted Peptide Assembles Into Homohexameric Complexes That Can Probably Associate With Pathogen Membranes And Also Insert Into These Membranes Where They Behave As Channels |
| Alternative Antibody Names | Anti-Dermcidin antibodyAnti-Preproteolysin Cleaved Into - Survival-Promoting Peptide - Dcd-1 antibodyAnti-DCD antibodyAnti-AIDD antibodyAnti-DSEP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and PDCD6 knockout (KO) 293T cells, using [KO Validated] PDCD6 Rabbit polyclonal antibody (STJ11100800) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89736/358213/STJ11100800_1__35533.1713122537.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and PDCD6 knockout (KO) 293T cells, using [KO Validated] PDCD6 Rabbit polyclonal antibody (STJ11100800) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
