Anti-DCD antibody (STJA0008441)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human DCD
General Information
| Short Description | Rabbit polyclonal anti-Dermcidin for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DCD |
| Gene ID | 117159 |
| Uniprot ID | DCD_HUMAN |
| Immunogen | Synthesized peptide derived from human DCD |
| Specificity | This antibody detects endogenous levels of DCD at Human |
Additional Info
| Function | DCD-1: Found in sweat, has an antimicrobial activity during early bacterial colonization. The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen membranes. Once inserted in bacteria membranes forms anion channels probably altering the transmembrane potential essential for bacterial survival. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues. Survival-promoting peptide: Promotes survival of neurons and displays phosphatase activity. It may bind IgG. |
| Protein Name | DermcidinPreproteolysin Cleaved Into - Survival-Promoting Peptide - Dcd-1 |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedSurvival-Promoting Peptide: SecretedDcd-1: SecretedMembranePeripheral Membrane ProteinSingle-Pass Membrane ProteinThe Secreted Peptide Assembles Into Homohexameric Complexes That Can Probably Associate With Pathogen Membranes And Also Insert Into These Membranes Where They Behave As Channels |
| Alternative Antibody Names | Anti-Dermcidin antibodyAnti-Preproteolysin Cleaved Into - Survival-Promoting Peptide - Dcd-1 antibodyAnti-DCD antibodyAnti-AIDD antibodyAnti-DSEP antibody |
Information sourced from Uniprot.org