| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-DBF4 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S1MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DBF4 |
| Gene ID: |
10926 |
| Uniprot ID: |
DBF4A_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DBF4 (Q9UBU7). |
| Immunogen Sequence: |
MNSGAMRIHSKGHFQGGIQV KNEKNRPSLKSLKTDNRPEK SKCKPLWGKVFYLDLPSVTI SEKLQKDIKDLGGRVEEFLS KDISYLISNKKEAKFAQTLG |
| Tissue Specificity | Highly expressed in testis and thymus. Expressed also in most cancer cells lines. |
| Post Translational Modifications | Phosphorylation increases its interaction with PSIP1. |
| Function | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. |
| Protein Name | Protein Dbf4 Homolog AActivator Of S Phase KinaseChiffon Homolog ADbf4-Type Zinc Finger-Containing Protein 1 |
| Database Links | Reactome: R-HSA-176187Reactome: R-HSA-68962 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Protein Dbf4 Homolog A antibodyAnti-Activator Of S Phase Kinase antibodyAnti-Chiffon Homolog A antibodyAnti-Dbf4-Type Zinc Finger-Containing Protein 1 antibodyAnti-DBF4 antibodyAnti-ASK antibodyAnti-DBF4A antibodyAnti-ZDBF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunoprecipitation analysis of 300 Mu g extracts from Jurkat cells using 3 Mu g [KD Validated] DNMT1 Rabbit monoclonal antibody (STJ11101761). Western blot was performed from the immunoprecipitate using DNMT1 (STJ11101761) at a dilution of 1:1000.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/90676/360693/STJ11101761_1__79926.1713125393.jpg?c=1 "Immunoprecipitation analysis of 300 Mu g extracts from Jurkat cells using 3 Mu g [KD Validated] DNMT1 Rabbit monoclonal antibody (STJ11101761). Western blot was performed from the immunoprecipitate using DNMT1 (STJ11101761) at a dilution of 1:1000.")
