Anti-DBF4 antibody (1-100) [S1MR] (STJ11103121)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal DBF4 (1-100) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S1MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DBF4 |
| Gene ID | 10926 |
| Uniprot ID | DBF4A_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MNSGAMRIHSKGHFQGGIQV KNEKNRPSLKSLKTDNRPEK SKCKPLWGKVFYLDLPSVTI SEKLQKDIKDLGGRVEEFLS KDISYLISNKKEAKFAQTLG |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DBF4 (Q9UBU7). |
Additional Info
| Tissue Specificity | Highly expressed in testis and thymus. Expressed also in most cancer cells lines. |
| Post Translational Modifications | Phosphorylation increases its interaction with PSIP1. |
| Function | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. |
| Protein Name | Protein Dbf4 Homolog AActivator Of S Phase KinaseChiffon Homolog ADbf4-Type Zinc Finger-Containing Protein 1 |
| Database Links | Reactome: R-HSA-176187Reactome: R-HSA-68962 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Protein Dbf4 Homolog A antibodyAnti-Activator Of S Phase Kinase antibodyAnti-Chiffon Homolog A antibodyAnti-Dbf4-Type Zinc Finger-Containing Protein 1 antibodyAnti-DBF4 antibodyAnti-ASK antibodyAnti-DBF4A antibodyAnti-ZDBF1 antibody |
Information sourced from Uniprot.org