| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | D2HGDH |
| Gene ID: | 728294 |
| Uniprot ID: | D2HDH_HUMAN |
| Immunogen Region: | 322-521 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 322-521 of human D2HGDH (NP_689996.4). |
| Immunogen Sequence: | GRHLHLASPVQESPFYVLIE TSGSNAGHDAEKLGHFLEHA LGSGLVTDGTMATDQRKVKM LWALRERITEALSRDGYVYK YDLSLPVERLYDIVTDLRAR LGPHAKHVVGYGHLGDGNLH LNVTAEAFSPSLLAALEPHV YEWTAGQQGSVSAEHGVGFR KRDVLGYSKPPGALQLMQQL KALLDPKGILNPYKTLPSQA |
| Function | Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC. |
| Protein Name | D-2-Hydroxyglutarate Dehydrogenase - Mitochondrial |
| Database Links | Reactome: R-HSA-880009 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-D-2-Hydroxyglutarate Dehydrogenase - Mitochondrial antibodyAnti-D2HGDH antibodyAnti-D2HGD antibody |
Information sourced from Uniprot.org