Anti-D2HGDH antibody (322-521) (STJ118653)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal D2HGDH (322-521) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | D2HGDH |
| Gene ID | 728294 |
| Uniprot ID | D2HDH_HUMAN |
| Immunogen Region | 322-521 |
| Immunogen Sequence | GRHLHLASPVQESPFYVLIE TSGSNAGHDAEKLGHFLEHA LGSGLVTDGTMATDQRKVKM LWALRERITEALSRDGYVYK YDLSLPVERLYDIVTDLRAR LGPHAKHVVGYGHLGDGNLH LNVTAEAFSPSLLAALEPHV YEWTAGQQGSVSAEHGVGFR KRDVLGYSKPPGALQLMQQL KALLDPKGILNPYKTLPSQA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 322-521 of human D2HGDH (NP_689996.4). |
Additional Info
| Function | Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC. |
| Protein Name | D-2-Hydroxyglutarate Dehydrogenase - Mitochondrial |
| Database Links | Reactome: R-HSA-880009 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-D-2-Hydroxyglutarate Dehydrogenase - Mitochondrial antibodyAnti-D2HGDH antibodyAnti-D2HGD antibody |
Information sourced from Uniprot.org