Anti-Cytochrome C antibody [SM5173] (STJA0005173)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG
ImmunogenKLH conjugated Synthetic peptide corresponding to Mouse Cytochrome c
General Information
| Short Description | Mouse monoclonal anti-Cytochrome C for use in WB, IHC and IF in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF |
| Host | Mouse |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM5173 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB (M, R) 1:500-1:1000IHC/IF (H, R) 1:500-1:1000/1:250-1:1000 |
| Formulation | PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | Cycs |
| Gene ID | 13063 |
| Uniprot ID | CYC_MOUSE |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Cytochrome c |
Additional Info
| Post Translational Modifications | Binds 1 heme c group covalently per subunit. Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration. |
| Function | Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. |
| Protein Name | Cytochrome C - Somatic |
| Database Links | Reactome: R-MMU-111457Reactome: -MMU-111458Reactome: -MMU-111459Reactome: -MMU-2151201Reactome: -MMU-3299685Reactome: -MMU-5620971Reactome: -MMU-5628897Reactome: -MMU-611105Reactome: -MMU-9627069Reactome: -MMU-9707564 |
| Cellular Localisation | Mitochondrion Intermembrane SpaceLoosely Associated With The Inner Membrane |
| Alternative Antibody Names | Anti-Cytochrome C - Somatic antibodyAnti-Cycs antibody |
Information sourced from Uniprot.org