| Tissue Specificity | Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung. |
| Function | Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis. Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis. Can also demethylate substrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL. |
| Protein Name | Lanosterol 14-Alpha DemethylaseLdmCypliCytochrome P450 51a1Cyp51a1Cytochrome P450-14dmCytochrome P45014dmCytochrome P450liSterol 14-Alpha Demethylase |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-211976Reactome: R-HSA-2426168Reactome: R-HSA-9619665 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Lanosterol 14-Alpha Demethylase antibodyAnti-Ldm antibodyAnti-Cypli antibodyAnti-Cytochrome P450 51a1 antibodyAnti-Cyp51a1 antibodyAnti-Cytochrome P450-14dm antibodyAnti-Cytochrome P45014dm antibodyAnti-Cytochrome P450li antibodyAnti-Sterol 14-Alpha Demethylase antibodyAnti-CYP51A1 antibodyAnti-CYP51 antibody |
Information sourced from Uniprot.org
