Anti-CYP2D6 antibody (20-230) (STJ111069)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CYP2D6 (20-230) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CYP2D6 |
| Gene ID | 1565 |
| Uniprot ID | CP2D6_HUMAN |
| Immunogen Region | 20-230 |
| Immunogen Sequence | VDLMHRRQRWAARYPPGPLP LPGLGNLLHVDFQNTPYCFD QLRRRFGDVFSLQLAWTPVV VLNGLAAVREALVTHGEDTA DRPPVPITQILGFGPRSQGV FLARYGPAWREQRRFSVSTL RNLGLGKKSLEQWVTEEAAC LCAAFANHSGRPFRPNGLLD KAVSNVIASLTCGRRFEYDD PRFLRLLDLAQEGLKEESGF LREVLNAVPVL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 20-230 of human CYP2D6 (NP_000097.3). |
Additional Info
| Function | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling. Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid. Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. |
| Protein Name | Cytochrome P450 2d6Cypiid6Cholesterol 25-HydroxylaseCytochrome P450-Db1Debrisoquine 4-Hydroxylase |
| Database Links | Reactome: R-HSA-211935Reactome: R-HSA-211958Reactome: R-HSA-211981Reactome: R-HSA-211999Reactome: R-HSA-9027307Reactome: R-HSA-9749641 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 2d6 antibodyAnti-Cypiid6 antibodyAnti-Cholesterol 25-Hydroxylase antibodyAnti-Cytochrome P450-Db1 antibodyAnti-Debrisoquine 4-Hydroxylase antibodyAnti-CYP2D6 antibodyAnti-CYP2DL1 antibody |
Information sourced from Uniprot.org