| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CYP2C18 (231-490) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP2C18 |
| Gene ID: |
1562 |
| Uniprot ID: |
CP2CI_HUMAN |
| Immunogen Region: |
231-490 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 231-490 of human CYP2C18 (NP_000763.1). |
| Immunogen Sequence: |
NKIAENFAYIKSYVLERIKE HQESLDMNSARDFIDCFLIK MEQEKHNQQSEFTVESLIAT VTDMFGAGTETTSTTLRYGL LLLLKYPEVTAKVQEEIECV VGRNRSPCMQDRSHMPYTDA VVHEIQRYIDLLPTNLPHAV TCDVKFKNYLIPKGTTIITS LTSVLHNDKEFPNPEMFDPG HFLDKSGNFKKSDYFMPFSA GKRMCMGEGLARMELFLFLT TILQNFNLKSQVDPKDIDI |
| Function | A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). |
| Protein Name | Cytochrome P450 2c18Cypiic18Cytochrome P450-6b/29c |
| Database Links | Reactome: R-HSA-211981 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 2c18 antibodyAnti-Cypiic18 antibodyAnti-Cytochrome P450-6b/29c antibodyAnti-CYP2C18 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
