| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CTSS |
| Gene ID: | 1520 |
| Uniprot ID: | CATS_HUMAN |
| Immunogen Region: | 115-331 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 115-331 of human CTSS (NP_004070.3). |
| Immunogen Sequence: | LPDSVDWREKGCVTEVKYQG SCGACWAFSAVGALEAQLKL KTGKLVSLSAQNLVDCSTEK YGNKGCNGGFMTTAFQYIID NKGIDSDASYPYKAMDQKCQ YDSKYRAATCSKYTELPYGR EDVLKEAVANKGPVSVGVDA RHPSFFLYRSGVYYEPSCTQ NVNHGVLVVGYGDLNGKEYW LVKNSWGHNFGEEGYIRMAR NKGNHCGIASFPSYPEI |
| Function | Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. |
| Protein Name | Cathepsin S |
| Database Links | Reactome: R-HSA-1236977 Reactome: R-HSA-1474228 Reactome: R-HSA-1679131 Reactome: R-HSA-2022090 Reactome: R-HSA-2132295 Reactome: R-HSA-6798695 |
| Cellular Localisation | Lysosome Secreted Cytoplasmic Vesicle Phagosome |
| Alternative Antibody Names | Anti-Cathepsin S antibody Anti-CTSS antibody |
Information sourced from Uniprot.org