Anti-CTNND2 antibody (966-1225) (STJ114507)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CTNND2 (966-1225) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:3000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CTNND2 |
| Gene ID | 1501 |
| Uniprot ID | CTND2_HUMAN |
| Immunogen Region | 966-1225 |
| Immunogen Sequence | TLHEVITKNMENAKALRDAG GIEKLVGISKSKGDKHSPKV VKAASQVLNSMWQYRDLRSL YKKDGWSQYHFVASSSTIER DRQRPYSSSRTPSISPVRVS PNNRSASAPASPREMISLKE RKTDYECTGSNATYHGAKGE HTSRKDAMTAQNTGISTLYR NSYGAPAEDIKHNQVSAQPV PQEPSRKDYETYQPFQNSTR NYDESFFEDQVHHRPPASEY TMHLGLKSTGNYVDFYSAA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 966-1225 of human CTNND2 (NP_001323.1). |
Additional Info
| Tissue Specificity | Expressed in brain.highest expression is observed in fetal brain. |
| Post Translational Modifications | O-glycosylated. Phosphorylated by CDK5. Phosphorylated by GSK3B. |
| Function | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation. Functions as a transcriptional activator when bound to ZBTB33. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. |
| Protein Name | Catenin Delta-2Delta-CateninGt24Neural Plakophilin-Related Arm-Repeat ProteinNprapNeurojungin |
| Database Links | |
| Cellular Localisation | NucleusCell JunctionAdherens JunctionCell ProjectionDendritePerikaryon |
| Alternative Antibody Names | Anti-Catenin Delta-2 antibodyAnti-Delta-Catenin antibodyAnti-Gt24 antibodyAnti-Neural Plakophilin-Related Arm-Repeat Protein antibodyAnti-Nprap antibodyAnti-Neurojungin antibodyAnti-CTNND2 antibodyAnti-NPRAP antibody |
Information sourced from Uniprot.org