| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CTNND2 (966-1225) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:3000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CTNND2 |
| Gene ID: |
1501 |
| Uniprot ID: |
CTND2_HUMAN |
| Immunogen Region: |
966-1225 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 966-1225 of human CTNND2 (NP_001323.1). |
| Immunogen Sequence: |
TLHEVITKNMENAKALRDAG GIEKLVGISKSKGDKHSPKV VKAASQVLNSMWQYRDLRSL YKKDGWSQYHFVASSSTIER DRQRPYSSSRTPSISPVRVS PNNRSASAPASPREMISLKE RKTDYECTGSNATYHGAKGE HTSRKDAMTAQNTGISTLYR NSYGAPAEDIKHNQVSAQPV PQEPSRKDYETYQPFQNSTR NYDESFFEDQVHHRPPASEY TMHLGLKSTGNYVDFYSAA |
| Tissue Specificity | Expressed in brain.highest expression is observed in fetal brain. |
| Post Translational Modifications | O-glycosylated. Phosphorylated by CDK5. Phosphorylated by GSK3B. |
| Function | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation. Functions as a transcriptional activator when bound to ZBTB33. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. |
| Protein Name | Catenin Delta-2Delta-CateninGt24Neural Plakophilin-Related Arm-Repeat ProteinNprapNeurojungin |
| Cellular Localisation | NucleusCell JunctionAdherens JunctionCell ProjectionDendritePerikaryon |
| Alternative Antibody Names | Anti-Catenin Delta-2 antibodyAnti-Delta-Catenin antibodyAnti-Gt24 antibodyAnti-Neural Plakophilin-Related Arm-Repeat Protein antibodyAnti-Nprap antibodyAnti-Neurojungin antibodyAnti-CTNND2 antibodyAnti-NPRAP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
