Anti-CST3 antibody (1-146) (STJ23251)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CST3 (1-146) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:10-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CST3 |
| Gene ID | 1471 |
| Uniprot ID | CYTC_HUMAN |
| Immunogen Region | 1-146 |
| Immunogen Sequence | MAGPLRAPLLLLAILAVALA VSPAAGSSPGKPPRLVGGPM DASVEEEGVRRALDFAVGEY NKASNDMYHSRALQVVRARK QIVAGVNYFLDVELGRTTCT KTQPNLDNCPFHDQPHLKRK AFCSFQIYAVPWQGTMTLSK STCQDA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-146 of human Cystatin C (NP_000090.1). |
Additional Info
| Tissue Specificity | Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland. |
| Post Translational Modifications | The Thr-25 variant is O-glycosylated with a core 1 or possibly core 8 glycan. The signal peptide of the O-glycosylated Thr-25 variant is cleaved between Ala-20 and Val-21. |
| Function | As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. |
| Protein Name | Cystatin-CCystatin-3Gamma-TraceNeuroendocrine Basic PolypeptidePost-Gamma-Globulin |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-6798695Reactome: R-HSA-8957275Reactome: R-HSA-977225 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Cystatin-C antibodyAnti-Cystatin-3 antibodyAnti-Gamma-Trace antibodyAnti-Neuroendocrine Basic Polypeptide antibodyAnti-Post-Gamma-Globulin antibodyAnti-CST3 antibody |
Information sourced from Uniprot.org