| Short Description : | Rabbit polyclonal CSF2RB (200-443) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CSF2RB |
| Gene ID: | 1439 |
| Uniprot ID: | IL3RB_HUMAN |
| Immunogen Region: | 200-443 |
| Immunogen Sequence: | EHLMPSSTYVARVRTRLAPG SRLSGRPSKWSPEVCWDSQP GDEAQPQNLECFFDGAAVLS CSWEVRKEVASSVSFGLFYK PSPDAGEEECSPVLREGLGS LHTRHHCQIPVPDPATHGQY IVSVQPRRAEKHIKSSVNIQ MAPPSLNVTKDGDSYSLRWE TMKMRYEHIDHTFEIQYRKD TATWKDSKTETLQNAHSMAL PALEPSTRYWARVRVRTSRT GYNGIWSEWSEARSWDTES |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-443 of human CSF2RB (NP_000386.1). |
| Post Translational Modifications | May be phosphorylated by LYN. |
| Function | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway. |
| Protein Name | Cytokine Receptor Common Subunit BetaCdw131Gm-Csf/Il-3/Il-5 Receptor Common Beta SubunitCd Antigen Cd131 |
| Database Links | Reactome: R-HSA-512988Reactome: R-HSA-5673001Reactome: R-HSA-5683826Reactome: R-HSA-5688849Reactome: R-HSA-5688890Reactome: R-HSA-912526 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cytokine Receptor Common Subunit Beta antibodyAnti-Cdw131 antibodyAnti-Gm-Csf/Il-3/Il-5 Receptor Common Beta Subunit antibodyAnti-Cd Antigen Cd131 antibodyAnti-CSF2RB antibodyAnti-IL3RB antibodyAnti-IL5RB antibody |
Information sourced from Uniprot.org
