| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CSF2RB (200-443) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CSF2RB |
| Gene ID: |
1439 |
| Uniprot ID: |
IL3RB_HUMAN |
| Immunogen Region: |
200-443 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 200-443 of human CSF2RB (NP_000386.1). |
| Immunogen Sequence: |
EHLMPSSTYVARVRTRLAPG SRLSGRPSKWSPEVCWDSQP GDEAQPQNLECFFDGAAVLS CSWEVRKEVASSVSFGLFYK PSPDAGEEECSPVLREGLGS LHTRHHCQIPVPDPATHGQY IVSVQPRRAEKHIKSSVNIQ MAPPSLNVTKDGDSYSLRWE TMKMRYEHIDHTFEIQYRKD TATWKDSKTETLQNAHSMAL PALEPSTRYWARVRVRTSRT GYNGIWSEWSEARSWDTES |
| Post Translational Modifications | May be phosphorylated by LYN. |
| Function | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway. |
| Protein Name | Cytokine Receptor Common Subunit BetaCdw131Gm-Csf/Il-3/Il-5 Receptor Common Beta SubunitCd Antigen Cd131 |
| Database Links | Reactome: R-HSA-512988Reactome: R-HSA-5673001Reactome: R-HSA-5683826Reactome: R-HSA-5688849Reactome: R-HSA-5688890Reactome: R-HSA-912526 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cytokine Receptor Common Subunit Beta antibodyAnti-Cdw131 antibodyAnti-Gm-Csf/Il-3/Il-5 Receptor Common Beta Subunit antibodyAnti-Cd Antigen Cd131 antibodyAnti-CSF2RB antibodyAnti-IL3RB antibodyAnti-IL5RB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
