Anti-CRYAB antibody (1-175 aa) [1D11C6E6] (STJ97971)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
ImmunogenPurified recombinant fragment of Crystallin-Alpha B (aa1-175) expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-Alpha-crystallin B chain-crystallin (1-175 aa) for use in WB, IHC, IF and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 1D11C6E6 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000IHC 1:200-1:1000ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CRYAB |
| Gene ID | 1410 |
| Uniprot ID | CRYAB_HUMAN |
| Immunogen | Purified recombinant fragment of Crystallin-Alpha B (aa1-175) expressed in E. Coli. |
| Immunogen Region | 1-175 aa |
| Specificity | Crystallin-Alpha B Monoclonal Antibody detects endogenous levels of Crystallin-Alpha B protein. |
Additional Info
| Function | May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome. |
| Protein Name | Alpha-Crystallin B ChainAlpha(B-CrystallinHeat Shock Protein Beta-5Hspb5Heat Shock Protein Family B Member 5Renal Carcinoma Antigen Ny-Ren-27Rosenthal Fiber Component |
| Database Links | Reactome: R-HSA-3371571 |
| Cellular Localisation | CytoplasmNucleusSecretedLysosomeTranslocates To The Nucleus During Heat Shock And Resides In Sub-Nuclear Structures Known As Sc35 Speckles Or Nuclear Splicing SpecklesLocalizes At The Z-Bands And The Intercalated Disk In CardiomyocytesCan Be SecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Antibody Names | Anti-Alpha-Crystallin B Chain antibodyAnti-Alpha(B-Crystallin antibodyAnti-Heat Shock Protein Beta-5 antibodyAnti-Hspb5 antibodyAnti-Heat Shock Protein Family B Member 5 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-27 antibodyAnti-Rosenthal Fiber Component antibodyAnti-CRYAB antibodyAnti-CRYA2 antibodyAnti-HSPB5 antibody |
Information sourced from Uniprot.org