![Anti-CRASH antibody [7B6] (STJ16101068)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149784/302533/STJ16101068_1__50559.1646940691.jpg?c=1 "Anti-CRASH antibody [7B6] (STJ16101068)")
![Anti-CRASH antibody [7B6] (STJ16101068)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149784/302534/STJ16101068_2__11396.1646940691.jpg?c=1 "Anti-CRASH antibody [7B6] (STJ16101068)")
![Anti-CRASH antibody [7B6] (STJ16101068)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149784/302533/STJ16101068_1__50559.1646940691.jpg?c=1 "Anti-CRASH antibody [7B6] (STJ16101068)")
| Host: | Mouse |
| Applications: | ELISA/WB/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-CRASH is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 7B6 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Formulation: | PBS with 0.02% Sodium Azide. |
| Purification: | Affinity purified from tissue culture. |
| Concentration: | Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL. |
| Dilution Range: | ELISA (solid phase: 0, 1-100 µg/ml; tracer: 0, 001-100 µg/ml for 30 min at RT). Immunoblotting (1-2 µg/ml). Immunohistology (formalin-fixed: 1-2 µg/ml for 30 min at RT; staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citra |
| Storage Instruction: | Store for up to 1 year at 2-8°C upon receipt. |
| Gene Symbol: | ASRGL1 |
| Gene ID: | 80150 |
| Uniprot ID: | ASGL1_HUMAN |
| Immunogen: | A BALB/c mouse was immunized with CRASH recombinant protein and synthetic peptide. Fusion partner: SP2/0. |
| Tissue Specificity | Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma. |
| Post Translational Modifications | Cleaved into an alpha and beta chain by autocatalysis.this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity. |
| Function | Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. |
| Protein Name | Isoaspartyl Peptidase/L-Asparaginase Asparaginase-Like Protein 1 Beta-Aspartyl-Peptidase Isoaspartyl Dipeptidase L-Asparagine Amidohydrolase Cleaved Into - Isoaspartyl Peptidase/L-Asparaginase Alpha Chain - Isoaspartyl Peptidase/L-Asparaginase Beta Chain |
| Database Links | Reactome: R-HSA-8964208 |
| Cellular Localisation | Cytoplasm Midpiece Of Sperm Tail |
| Alternative Antibody Names | Anti-Isoaspartyl Peptidase/L-Asparaginase antibody Anti-Asparaginase-Like Protein 1 antibody Anti-Beta-Aspartyl-Peptidase antibody Anti-Isoaspartyl Dipeptidase antibody Anti-L-Asparagine Amidohydrolase Cleaved Into - Isoaspartyl Peptidase/L-Asparaginase Alpha Chain - Isoaspartyl Peptidase/L-Asparaginase Beta Chain antibody Anti-ASRGL1 antibody Anti-ALP antibody Anti-CRASH antibody |
Information sourced from Uniprot.org