| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CRADD (1-199) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CRADD |
| Gene ID: |
8738 |
| Uniprot ID: |
CRADD_HUMAN |
| Immunogen Region: |
1-199 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human RAIDD/RAIDD/CRADD (NP_003796.1). |
| Immunogen Sequence: |
MEARDKQVLRSLRLELGAEV LVEGLVLQYLYQEGILTENH IQEINAQTTGLRKTMLLLDI LPSRGPKAFDTFLDSLQEFP WVREKLKKAREEAMTDLPAG DRLTGIPSHILNSSPSDRQI NQLAQRLGPEWEPMVLSLGL SQTDIYRCKANHPHNVQSQV VEAFIRWRQRFGKQATFQSL HNGLRAVEVDPSLLLHMLE |
| Tissue Specificity | Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. |
| Function | Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway. |
| Protein Name | Death Domain-Containing Protein CraddCaspase And Rip Adapter With Death DomainRip-Associated Protein With A Death Domain |
| Database Links | Reactome: R-HSA-6803207 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Death Domain-Containing Protein Cradd antibodyAnti-Caspase And Rip Adapter With Death Domain antibodyAnti-Rip-Associated Protein With A Death Domain antibodyAnti-CRADD antibodyAnti-RAIDD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
