| Short Description : | Rabbit polyclonal CRADD (1-199) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CRADD |
| Gene ID: | 8738 |
| Uniprot ID: | CRADD_HUMAN |
| Immunogen Region: | 1-199 |
| Immunogen Sequence: | MEARDKQVLRSLRLELGAEV LVEGLVLQYLYQEGILTENH IQEINAQTTGLRKTMLLLDI LPSRGPKAFDTFLDSLQEFP WVREKLKKAREEAMTDLPAG DRLTGIPSHILNSSPSDRQI NQLAQRLGPEWEPMVLSLGL SQTDIYRCKANHPHNVQSQV VEAFIRWRQRFGKQATFQSL HNGLRAVEVDPSLLLHMLE |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human RAIDD/RAIDD/CRADD (NP_003796.1). |
| Tissue Specificity | Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. |
| Function | Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway. |
| Protein Name | Death Domain-Containing Protein CraddCaspase And Rip Adapter With Death DomainRip-Associated Protein With A Death Domain |
| Database Links | Reactome: R-HSA-6803207 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Death Domain-Containing Protein Cradd antibodyAnti-Caspase And Rip Adapter With Death Domain antibodyAnti-Rip-Associated Protein With A Death Domain antibodyAnti-CRADD antibodyAnti-RAIDD antibody |
Information sourced from Uniprot.org
