| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:2000-1:8000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CPT1C |
| Gene ID: |
126129 |
| Uniprot ID: |
CPT1C_HUMAN |
| Immunogen Region: |
270-400 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 270-400 of human CPT1C (NP_001129524.1). |
| Immunogen Sequence: |
LYRHRLNRQEIPPTLLMGMR PLCSAQYEKIFNTTRIPGVQ KDYIRHLHDSQHVAVFHRGR FFRMGTHSRNSLLSPRALEQ QFQRILDDPSPACPHEEHLA ALTAAPRGTWAQVRTSLKTQ AAEALEAVEGA |
| Tissue Specificity | Expressed predominantly in brain and testis. Expressed in motor neurons. |
| Function | Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1. Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner. Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control. Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels. |
| Protein Name | Palmitoyl Thioesterase Cpt1cCarnitine O-Palmitoyltransferase 1 - Brain IsoformCpti-BCarnitine Palmitoyltransferase 1cCarnitine Palmitoyltransferase ICpt I-C |
| Cellular Localisation | Cell ProjectionDendriteAxonEndoplasmic Reticulum MembraneMulti-Pass Membrane ProteinLocalized In The Soma And Dendritic And Axonal Projections |
| Alternative Antibody Names | Anti-Palmitoyl Thioesterase Cpt1c antibodyAnti-Carnitine O-Palmitoyltransferase 1 - Brain Isoform antibodyAnti-Cpti-B antibodyAnti-Carnitine Palmitoyltransferase 1c antibodyAnti-Carnitine Palmitoyltransferase I antibodyAnti-Cpt I-C antibodyAnti-CPT1C antibodyAnti-CATL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
