| Function | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF7 activates directly the mRNA 3'-processing machinery. Binds to pA signals in RNA substrates. |
| Protein Name | Cleavage And Polyadenylation Specificity Factor Subunit 7Cleavage And Polyadenylation Specificity Factor 59 Kda SubunitCpsf 59 Kda SubunitCleavage Factor Im Complex 59 Kda SubunitCfim59Pre-Mrna Cleavage Factor Im 59 Kda Subunit |
| Database Links | Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856Reactome: R-HSA-77595Reactome: R-HSA-9013422 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Nucleus And The Cytoplasm In A Transcription- And Xpo1/Crm1-Independent MannerMost Probably In Complex With The Cleavage Factor Im Complex (Cfim) |
| Alternative Antibody Names | Anti-Cleavage And Polyadenylation Specificity Factor Subunit 7 antibodyAnti-Cleavage And Polyadenylation Specificity Factor 59 Kda Subunit antibodyAnti-Cpsf 59 Kda Subunit antibodyAnti-Cleavage Factor Im Complex 59 Kda Subunit antibodyAnti-Cfim59 antibodyAnti-Pre-Mrna Cleavage Factor Im 59 Kda Subunit antibodyAnti-CPSF7 antibody |
Information sourced from Uniprot.org
