Anti-CPSF7 antibody (STJA0008688)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human CPSF7
General Information
| Short Description | Rabbit polyclonal anti-Cleavage and polyadenylation specificity factor subunit 7 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CPSF7 |
| Gene ID | 79869 |
| Uniprot ID | CPSF7_HUMAN |
| Immunogen | Synthesized peptide derived from human CPSF7 |
| Specificity | This antibody detects endogenous levels of CPSF7 at Human, Mouse, Rat |
Additional Info
| Function | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF7 activates directly the mRNA 3'-processing machinery. Binds to pA signals in RNA substrates. |
| Protein Name | Cleavage And Polyadenylation Specificity Factor Subunit 7Cleavage And Polyadenylation Specificity Factor 59 Kda SubunitCpsf 59 Kda SubunitCleavage Factor Im Complex 59 Kda SubunitCfim59Pre-Mrna Cleavage Factor Im 59 Kda Subunit |
| Database Links | Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856Reactome: R-HSA-77595Reactome: R-HSA-9013422 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Nucleus And The Cytoplasm In A Transcription- And Xpo1/Crm1-Independent MannerMost Probably In Complex With The Cleavage Factor Im Complex (Cfim) |
| Alternative Antibody Names | Anti-Cleavage And Polyadenylation Specificity Factor Subunit 7 antibodyAnti-Cleavage And Polyadenylation Specificity Factor 59 Kda Subunit antibodyAnti-Cpsf 59 Kda Subunit antibodyAnti-Cleavage Factor Im Complex 59 Kda Subunit antibodyAnti-Cfim59 antibodyAnti-Pre-Mrna Cleavage Factor Im 59 Kda Subunit antibodyAnti-CPSF7 antibody |
Information sourced from Uniprot.org