| Tissue Specificity | Predominantly found in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain. |
| Function | Catalyzes the second reaction in the biosynthesis of heme A, a prosthetic group of mitochondrial cytochrome c oxidase (CcO). Heme A is synthesized from heme B by two sequential enzymatic reactions catalyzed by heme O synthase (HOS) and heme A synthase (HAS). HAS catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8, in a reaction that involves matrix ferredoxin and ferredoxin reductase. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A. |
| Protein Name | Heme A Synthase Cox15HasCytochrome C Oxidase Assembly Protein Cox15 Homolog |
| Database Links | Reactome: R-HSA-189451Reactome: R-HSA-9864848 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Heme A Synthase Cox15 antibodyAnti-Has antibodyAnti-Cytochrome C Oxidase Assembly Protein Cox15 Homolog antibodyAnti-COX15 antibody |
Information sourced from Uniprot.org
