| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-COQ7 (37-217) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
COQ7 |
| Gene ID: |
10229 |
| Uniprot ID: |
COQ7_HUMAN |
| Immunogen Region: |
37-217 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 37-217 of human COQ7 (NP_057222.2). |
| Immunogen Sequence: |
SGMTLDNISRAAVDRIIRVD HAGEYGANRIYAGQMAVLGR TSVGPVIQKMWDQEKDHLKK FNELMVTFRVRPTVLMPLWN VLGFALGAGTALLGKEGAMA CTVAVEESIAHHYNNQIRTL MEEDPEKYEELLQLIKKFRD EELEHHDIGLDHDAELAPAY AVLKSIIQAGCRVAIYLSER L |
| Tissue Specificity | Expressed dominantly in heart and skeletal muscle. |
| Function | Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner. Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis. |
| Protein Name | 5-Demethoxyubiquinone Hydroxylase - MitochondrialDmq HydroxylaseTiming Protein Clk-1 HomologUbiquinone Biosynthesis Monooxygenase Coq7 |
| Database Links | Reactome: R-HSA-2142789 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix SideMitochondrionNucleusChromosome |
| Alternative Antibody Names | Anti-5-Demethoxyubiquinone Hydroxylase - Mitochondrial antibodyAnti-Dmq Hydroxylase antibodyAnti-Timing Protein Clk-1 Homolog antibodyAnti-Ubiquinone Biosynthesis Monooxygenase Coq7 antibodyAnti-COQ7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
