| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | COQ7 |
| Gene ID: | 10229 |
| Uniprot ID: | COQ7_HUMAN |
| Immunogen Region: | 37-217 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-217 of human COQ7 (NP_057222.2). |
| Immunogen Sequence: | SGMTLDNISRAAVDRIIRVD HAGEYGANRIYAGQMAVLGR TSVGPVIQKMWDQEKDHLKK FNELMVTFRVRPTVLMPLWN VLGFALGAGTALLGKEGAMA CTVAVEESIAHHYNNQIRTL MEEDPEKYEELLQLIKKFRD EELEHHDIGLDHDAELAPAY AVLKSIIQAGCRVAIYLSER L |
| Tissue Specificity | Expressed dominantly in heart and skeletal muscle. |
| Function | Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner. Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis. |
| Protein Name | 5-Demethoxyubiquinone Hydroxylase - Mitochondrial Dmq Hydroxylase Timing Protein Clk-1 Homolog Ubiquinone Biosynthesis Monooxygenase Coq7 |
| Database Links | Reactome: R-HSA-2142789 |
| Cellular Localisation | Mitochondrion Inner Membrane Peripheral Membrane Protein Matrix Side Mitochondrion Nucleus Chromosome |
| Alternative Antibody Names | Anti-5-Demethoxyubiquinone Hydroxylase - Mitochondrial antibody Anti-Dmq Hydroxylase antibody Anti-Timing Protein Clk-1 Homolog antibody Anti-Ubiquinone Biosynthesis Monooxygenase Coq7 antibody Anti-COQ7 antibody |
Information sourced from Uniprot.org