| Function | FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-decaprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid. Also acts downstream of COQ4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-decaprenyl)phenol to 2-methoxy-6-(all-trans-decaprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to COQ6 from NADPH via a ferredoxin/ferredoxin reductase system composed of FDX2 and FDXR. |
| Protein Name | Ubiquinone Biosynthesis Monooxygenase Coq6 - Mitochondrial2-Methoxy-6-Polyprenolphenol 4-HydroxylaseCoenzyme Q10 Monooxygenase 6 |
| Database Links | Reactome: R-HSA-2142789 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix SideGolgi ApparatusCell ProjectionLocalizes To Cell Processes And Golgi Apparatus In Podocytes |
| Alternative Antibody Names | Anti-Ubiquinone Biosynthesis Monooxygenase Coq6 - Mitochondrial antibodyAnti-2-Methoxy-6-Polyprenolphenol 4-Hydroxylase antibodyAnti-Coenzyme Q10 Monooxygenase 6 antibodyAnti-COQ6 antibodyAnti-CGI-10 antibody |
Information sourced from Uniprot.org
