Anti-COQ6 antibody (STJA0007072)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human COQ6
General Information
| Short Description | Rabbit polyclonal anti-Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | COQ6 |
| Gene ID | 51004 |
| Uniprot ID | COQ6_HUMAN |
| Immunogen | Synthesized peptide derived from human COQ6 |
| Specificity | This antibody detects endogenous levels of COQ6 at Human, Mouse, Rat |
Additional Info
| Function | FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-decaprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid. Also acts downstream of COQ4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-decaprenyl)phenol to 2-methoxy-6-(all-trans-decaprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to COQ6 from NADPH via a ferredoxin/ferredoxin reductase system composed of FDX2 and FDXR. |
| Protein Name | Ubiquinone Biosynthesis Monooxygenase Coq6 - Mitochondrial2-Methoxy-6-Polyprenolphenol 4-HydroxylaseCoenzyme Q10 Monooxygenase 6 |
| Database Links | Reactome: R-HSA-2142789 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix SideGolgi ApparatusCell ProjectionLocalizes To Cell Processes And Golgi Apparatus In Podocytes |
| Alternative Antibody Names | Anti-Ubiquinone Biosynthesis Monooxygenase Coq6 - Mitochondrial antibodyAnti-2-Methoxy-6-Polyprenolphenol 4-Hydroxylase antibodyAnti-Coenzyme Q10 Monooxygenase 6 antibodyAnti-COQ6 antibodyAnti-CGI-10 antibody |
Information sourced from Uniprot.org