Anti-COL4A5 antibody (1462-1691) (STJ111851)

Name: Anti-COL4A5 antibody (1462-1691) (STJ111851)
SKU: STJ111851
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ111851

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Short Description	Rabbit polyclonal COL4A5 (1462-1691) antibody for use in WB, IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 IF/ICC:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	COL4A5
Gene ID	1287
Uniprot ID	CO4A5_HUMAN
Immunogen Region	1462-1691
Immunogen Sequence	SSVAHGFLITRHSQTTDAPQ CPQGTLQVYEGFSLLYVQGN KRAHGQDLGTAGSCLRRFST MPFMFCNINNVCNFASRNDY SYWLSTPEPMPMSMQPLKGQ SIQPFISRCAVCEAPAVVIA VHSQTIQIPHCPQGWDSLWI GYSFMMHTSAGAEGSGQALA SPGSCLEEFRSAPFIECHGR GTCNYYANSYSFWLATVDVS DMFSKPQSETLKAGDLRTRI SRCQVCMKRT
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 1462-1691 of human COL4A5 (NP_203699.1).

Tissue Specificity	Isoform 2 is found in kidney.
Post Translational Modifications	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.
Function	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Protein Name	Collagen Alpha-5(Iv Chain
Database Links	Reactome: R-HSA-1442490 Reactome: R-HSA-1474244 Reactome: R-HSA-1650814 Reactome: R-HSA-186797 Reactome: R-HSA-2022090 Reactome: R-HSA-216083 Reactome: R-HSA-2214320 Reactome: R-HSA-2243919 Reactome: R-HSA-3000157 Reactome: R-HSA-3000171 Reactome: R-HSA-3000178 Reactome: R-HSA-419037 Reactome: R-HSA-8948216 Reactome: R-HSA-9010553
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix Basement Membrane
Alternative Antibody Names	Anti-Collagen Alpha-5(Iv Chain antibody Anti-COL4A5 antibody

Information sourced from Uniprot.org