Anti-COL25A1 antibody (NC2-2 region) (STJA0005755)

SKU:
STJA0005755-100

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CLAC-P (NC2-2 region) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 0.02% NaN3
Purification: Antigen Affinity Purified
Dilution Range: WB 1:500-1:1000
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: COL25A1
Gene ID: 84570
Uniprot ID: COPA1_HUMAN
Immunogen Region: NC2-2 region
Specificity: Reacts with the NC2-2 region of human and mouse CLAC-P. Detects bands of 50, 70 and 100 kDa in SPs of AD brain, but not in diffuse plaques of non-demented aged individuals, diffuse deposits in sub-cortical structures and cerebellum in AD nor in cereb
Immunogen: Synthetic peptide corresponding to amino acids from the NC2-2 region of human CLAC-P
Post Translational Modifications Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component. Glycosylated. Hydroxylated on 11% of proline residues and 49% of lysine residues.
Function Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
Protein Name Collagen Alpha-1(Xxv Chain
Alzheimer Disease Amyloid-Associated Protein
Amy
Clac-P Cleaved Into - Collagen-Like Alzheimer Amyloid Plaque Component
Clac
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-1650814
Reactome: R-HSA-8948216
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
After Proteolytic Cleavage
Clac Is Secreted
Alternative Antibody Names Anti-Collagen Alpha-1(Xxv Chain antibody
Anti-Alzheimer Disease Amyloid-Associated Protein antibody
Anti-Amy antibody
Anti-Clac-P Cleaved Into - Collagen-Like Alzheimer Amyloid Plaque Component antibody
Anti-Clac antibody
Anti-COL25A1 antibody

Information sourced from Uniprot.org

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