| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLAC-P (NC2-2 region) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS + 0.02% NaN3 |
| Purification: |
Antigen Affinity Purified |
| Dilution Range: |
WB 1:500-1:1000IHCICCIP |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
COL25A1 |
| Gene ID: |
84570 |
| Uniprot ID: |
COPA1_HUMAN |
| Immunogen Region: |
NC2-2 region |
| Specificity: |
Reacts with the NC2-2 region of human and mouse CLAC-P. Detects bands of 50, 70 and 100 kDa in SPs of AD brain, but not in diffuse plaques of non-demented aged individuals, diffuse deposits in sub-cortical structures and cerebellum in AD nor in cereb |
| Immunogen: |
Synthetic peptide corresponding to amino acids from the NC2-2 region of human CLAC-P |
| Post Translational Modifications | Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component. Glycosylated. Hydroxylated on 11% of proline residues and 49% of lysine residues. |
| Function | Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. |
| Protein Name | Collagen Alpha-1(Xxv ChainAlzheimer Disease Amyloid-Associated ProteinAmyClac-P Cleaved Into - Collagen-Like Alzheimer Amyloid Plaque ComponentClac |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1650814Reactome: R-HSA-8948216 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane ProteinAfter Proteolytic CleavageClac Is Secreted |
| Alternative Antibody Names | Anti-Collagen Alpha-1(Xxv Chain antibodyAnti-Alzheimer Disease Amyloid-Associated Protein antibodyAnti-Amy antibodyAnti-Clac-P Cleaved Into - Collagen-Like Alzheimer Amyloid Plaque Component antibodyAnti-Clac antibodyAnti-COL25A1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
