Anti-Cofilin 2 antibody (C-Term) (STJ70757)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Cofilin 2 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 18kDa band observed in Human Skeletal Muscle lysates and in Rat Heart lysates (calculated MW of 18.7kDa according to NP_068733.1and NP_619579.1). Recommended concentration: 0.0 |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CFL2 |
| Gene ID | 1073 |
| Uniprot ID | COF2_HUMAN |
| Accession Number | NP_068733.1; NP_619579.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | DIKDRSTLGEK |
| Specificity | This antibody is expected to recognise both reported isoforms (NP_068733 and NP_619579) |
Additional Info
| Post Translational Modifications | The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal. |
| Function | Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere. |
| Protein Name | Cofilin-2Cofilin - Muscle Isoform |
| Cellular Localisation | Nucleus MatrixCytoplasmCytoskeletonColocalizes With Cspr3 In The Z Line Of Sarcomeres |
| Alternative Antibody Names | Anti-Cofilin-2 antibodyAnti-Cofilin - Muscle Isoform antibodyAnti-CFL2 antibody |
Information sourced from Uniprot.org