| Short Description : | Rabbit polyclonal CNOT8 (1-292) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CNOT8 |
| Gene ID: | 9337 |
| Uniprot ID: | CNOT8_HUMAN |
| Immunogen Region: | 1-292 |
| Immunogen Sequence: | MPAALVENSQVICEVWASNL EEEMRKIREIVLSYSYIAMD TEFPGVVVRPIGEFRSSIDY QYQLLRCNVDLLKIIQLGLT FTNEKGEYPSGINTWQFNFK FNLTEDMYSQDSIDLLANSG LQFQKHEEEGIDTLHFAELL MTSGVVLCDNVKWLSFHSGY DFGYMVKLLTDSRLPEEEHE FFHILNLFFPSIYDVKYLMK SCKNLKGGLQEVADQLDLQR IGRQHQAGSDSLLTGMAFF |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human CNOT8 (NP_004770.4). |
| Function | Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex also seems to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 8Caf1-Like ProteinCalifpCaf2Ccr4-Associated Factor 8Caf1b |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-6804115Reactome: R-HSA-9820841 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ccr4-Not Transcription Complex Subunit 8 antibodyAnti-Caf1-Like Protein antibodyAnti-Califp antibodyAnti-Caf2 antibodyAnti-Ccr4-Associated Factor 8 antibodyAnti-Caf1b antibodyAnti-CNOT8 antibodyAnti-CALIF antibodyAnti-POP2 antibody |
Information sourced from Uniprot.org
