Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | CNOT8 |
Gene ID: | 9337 |
Uniprot ID: | CNOT8_HUMAN |
Immunogen Region: | 1-292 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human CNOT8 (NP_004770.4). |
Immunogen Sequence: | MPAALVENSQVICEVWASNL EEEMRKIREIVLSYSYIAMD TEFPGVVVRPIGEFRSSIDY QYQLLRCNVDLLKIIQLGLT FTNEKGEYPSGINTWQFNFK FNLTEDMYSQDSIDLLANSG LQFQKHEEEGIDTLHFAELL MTSGVVLCDNVKWLSFHSGY DFGYMVKLLTDSRLPEEEHE FFHILNLFFPSIYDVKYLMK SCKNLKGGLQEVADQLDLQR IGRQHQAGSDSLLTGMAFF |
Function | Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. |
Protein Name | Ccr4-Not Transcription Complex Subunit 8 Caf1-Like Protein Califp Caf2 Ccr4-Associated Factor 8 Caf1b |
Database Links | Reactome: R-HSA-429947 Reactome: R-HSA-6804115 Reactome: R-HSA-9820841 |
Cellular Localisation | Cytoplasm Nucleus |
Alternative Antibody Names | Anti-Ccr4-Not Transcription Complex Subunit 8 antibody Anti-Caf1-Like Protein antibody Anti-Califp antibody Anti-Caf2 antibody Anti-Ccr4-Associated Factor 8 antibody Anti-Caf1b antibody Anti-CNOT8 antibody Anti-CALIF antibody Anti-POP2 antibody |
Information sourced from Uniprot.org