| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-CNGB3 (175-186) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-2-4µg/mlELISA-antibody detection limit dilution 1:8000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
CNGB3 |
| Gene ID: |
54714 |
| Uniprot ID: |
CNGB3_HUMAN |
| Immunogen Region: |
175-186 |
| Accession Number: |
NP_061971.3 |
| Immunogen Sequence: |
ESDDKPTEHYYR |
| Function | Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. |
| Protein Name | Cyclic Nucleotide-Gated Cation Channel Beta-3Cone Photoreceptor Cgmp-Gated Channel Subunit BetaCyclic Nucleotide-Gated Cation Channel Modulatory SubunitCyclic Nucleotide-Gated Channel Beta-3Cng Channel Beta-3 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cyclic Nucleotide-Gated Cation Channel Beta-3 antibodyAnti-Cone Photoreceptor Cgmp-Gated Channel Subunit Beta antibodyAnti-Cyclic Nucleotide-Gated Cation Channel Modulatory Subunit antibodyAnti-Cyclic Nucleotide-Gated Channel Beta-3 antibodyAnti-Cng Channel Beta-3 antibodyAnti-CNGB3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
